CADET

CADET (Chromatography Analysis and Design Toolkit) is a free and open-source command-line simulation framework that gives users the possibility to solve the General Rate Model (GRM) of packed bed liquid chromatography, as well as partial differential algebraic equations (PDAE) based on the finite volume method and the WENO scheme.
Besides Windows, the application is available for Linux and Mac OS X systems. It features support for many GRM variants and includes a native MATLAB interface (MEX) with standard routines and examples for helping users estimate parameters, optimize processes and perform experimental designs. XML and HDF5 data formats are supported too. Meanwhile, memory parallelization can be shared via OpenMP
The syntax is cadet-cli [-L ] [--] [--version] [-h] , which can be reviewed by calling the process' name without any arguments. Therefore, in addition to the input and output file, you can indicate the log level, instruct the tool to ignore the remaining labeled arguments after a specific flag, as well as to display the version and usage information, then immediately exit.
The downloaded package is lightweight and contains bindings and units. Tutorials are available at the developer's website for installing and building CADET. It can also be tested in an online simulator web service.