VirusTotal Uploader

VirusTotal has become a very popular service for scanning relatively small files, as it aggregates numerous antivirus engines to help you figure out if a file is dangerous while also enabling you to identify false positives.
Since the official desktop scanner is not being updated regularly, a third-party solution like VirusTotal Uploader may be what you need.

Upload files to VirusTotal from a simple desktop UI

Before anything else, you will need to provide a VirusTotal API key. To get one, simply create a VirusTotal account and access your profile. When you have it, open the application's settings and paste it in the designated field.
To scan a file, you can just drop it inside the main UI. If it has already been uploaded, you have the option of either viewing the last scan log or scanning it again. When the results are available, they will be opened in your default browser.

Scan files directly from the context menu

Alternatively, you can integrate the application into the context menu to speed up your scans. However, you cannot re-upload files that have already been scanned when using this method.
Also, we noticed that VirusTotal Uploader occasionally triggers an error message when attempting to scan files from the context menu. It is unclear why this happens, but it only seems to affect items on certain drives that have spaces in their file path.

Time-saving utility that needs more work

Following a GUI update in 2017, the VirusTotal service also saw the file size limit doubled to 256 MB. Unfortunately, though, possibly for technical reasons, this application still uses the old UI when uploading, which means it is limited to files up to 128 MB in size.
All in all, VirusTotal Uploader is a promising piece of software that still has to be improved in a few respects. It is in the early stages of development, however, so we hope the remaining issues will be fixed soon.